A Time-Domain Hybrid Analysis Method for Detecting and Quantifying T-Wave Alternans

A Time-Domain Hybrid Analysis Method for Detecting and Quantifying T-Wave Alternans

T-wave alternans (TWA) in surface electrocardiograph (ECG) signals has been recognized as a marker of cardiac electrical instability and is hypothesized to be associated with increased risk for ventricular arrhythmias among patients. A novel time-domain TWA hybrid analysis method (HAM) utilizing the correlation method and least squares regression technique is described in this paper. Simulated ...

Malignant T-wave alternans.

A36-year-old woman was referred after her son had syncopal episodes associated with a markedly prolonged QT interval, which was treated with b-blockers and a subsequent pacemaker. The mother had a history of “seizures” as a child that had been treated with various medications, which did not appear to affect her events. She continued to have episodes 2 to 3 times a year, and witnesses said she w...

Drug-induced T wave alternans.

{T} Wave Alternans Features for Automated Detection

T wave features suitable for automatic T wave alternans detection in low signal-to-noise ratio electrocardiograms are explored using a correlation-to-template-based algorithm for detecting T waves of variable duration. Amplitude and area features of T waves are found to be notably less sensitive to template selection than are duration features. T wave alternans features and measures which can b...

T-wave alternans: clinical performance, limitations and analysis methodologies.

Accurate recognition of individuals at higher immediate risk of sudden cardiac death (SCD) is still an open question. The fortuitous nature of acute cardiovascular events just does not seem to fit the well-known model of ventricular tachycardia/fibrillation induction in a static arrhythmogenic substrate by a synchronous trigger. On the mechanism of SCD, a dynamical electrical instability would ...